Author(s): Daum G, EisenmannTappe I, Fries HW, Troppmair J, Rapp UR
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Abstract Raf kinases are signal-integrating enzymes that have the ability to switch tyrosine kinase signalling to serine/threonine phosphorylation and connect growth factor receptors with transcription factors. The connection involves a cascade of protein kinases that is essential for cellular proliferation and differentiation of species ranging from worms to humans. This cascade also mediates transformation by most oncogenes.
This article was published in Trends Biochem Sci
and referenced in Journal of Biodiversity, Bioprospecting and Development