alexa The interleukin 2 gene is expressed in the syncytiotrophoblast of the human placenta.


Journal of Immunobiology

Author(s): Boehm KD, Kelley MF, Ilan J, Ilan J, Boehm KD, Kelley MF, Ilan J, Ilan J, Boehm KD, Kelley MF, Ilan J, Ilan J, Boehm KD, Kelley MF, Ilan J, Ilan J

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Abstract The lymphokine interleukin 2 is an important immune system regulatory glycopolypeptide. It is produced by antigen- or mitogen-stimulated T lymphocytes and is required for the proliferation or clonal expansion of activated T lymphocytes. In this report, it is demonstrated by RNA transfer blot hybridization that the poly(A)+ RNA population of the human placenta contains a 0.85-kilobase RNA transcript that specifically hybridizes to a human interleukin 2 cDNA probe. By using hybridization histochemistry in situ, it is further shown that interleukin 2 RNA transcripts are localized, primarily, to the syncytial (syncytiotrophoblast) layer of the human placenta. Possible roles for syncytiotrophoblast-produced interleukin 2 are suggested and discussed.
This article was published in Proc Natl Acad Sci U S A and referenced in Journal of Immunobiology

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