alexa The localizing value of asymmetry in pupillary size in severe head injury: relation to lesion type and location.
Neurology

Neurology

Journal of Spine

Author(s): Chesnut RM, Gautille T, Blunt BA, Klauber MR, Marshall LE

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Abstract Reliable Assessment of the probability that a head injury patient harbors a surgical intracranial lesion is critical to both triage and treatment. The authors analyzed data from 608 patients with severe head injuries (Glasgow Coma Scale score, < or = 8) in the Traumatic Coma Data Bank to assess the reliability of pupillary asymmetry in predicting the presence and location of an intracranial mass lesion. Of 210 patients with pupillary asymmetry of > or = 1 mm, 63 (30\%) had intracranial mass lesions, 52 (25\%) of which were extra-axial in location, 38 (73\%) of these located ipsilateral to the larger pupil. Of 51 patients with asymmetry of > or = 3 mm, 22 (43\%) had intracranial mass lesions, 18 (35\%) of which were extra-axial in location, 14 (64\%) of these located ipsilateral to the larger pupil. For both asymmetry categories, strong interactions were found with age and mechanism of injury, the highest incidence of extra-axial lesions occurring in older patients injured other than as occupants of motor vehicles. The authors developed regression equations that provide a graphic means to predict the presence of an intracranial hematoma using data on pupillary asymmetry, age, and mechanism of injury. This predictive model, interpreted in a hospital- and patient-specific fashion, should be of significant use in directing triage, activating diagnostic and therapeutic resources, and evaluating the utility of exploratory trephination.
This article was published in Neurosurgery and referenced in Journal of Spine

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