alexa The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Steroids & Hormonal Science

Author(s): Flaster H, Bernhagen J, Calandra T, Bucala R

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Abstract The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases. This article was published in Mol Endocrinol and referenced in Journal of Steroids & Hormonal Science

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