alexa The microRNA-producing enzyme Dicer1 is essential for zebrafish development.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Wienholds E, Koudijs MJ, van Eeden FJ, Cuppen E, Plasterk RH

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Abstract MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of the dicer1 gene in zebrafish. We observed an initial build-up of miRNA levels, produced by maternal Dicer1, in homozygous dicer1 mutants, but miRNA accumulation stopped after a few days. This resulted in developmental arrest around day 10. These results indicate that miRNA-producing Dicer1 is essential for vertebrate development. This article was published in Nat Genet and referenced in Journal of Stem Cell Research & Therapy

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