alexa The modified hole board as a differential screen for behavior in rodents.
Diabetes & Endocrinology

Diabetes & Endocrinology

Endocrinology & Metabolic Syndrome

Author(s): Ohl F, Holsboer F, Landgraf R

Abstract Share this page

Abstract We describe a modified hole board (mHB) paradigm as a test for unconditioned behavior in rodents that is aimed at analyzing a variety of behavioral dimensions. We demonstrate that the mHB enables the investigation of different behavioral dimensions in rodents in only one test by reproducing the behavioral characteristics previously collected from multiple behavioral tests in rats bred for either high or low anxiety-related behavior. In addition, the test design, which allows the experimental animal to maintain social contact with its group mates during the test, was shown to minimize stress for experimental animals and, moreover, to enable the investigator to assess social affinity among group mates. In summary, the mHB test enables animal models to be comprehensively phenotyped, while simultaneously reducing the number of animals and the amount of time required. Therefore, the mHB represents an alternative to the common practice of using a series of more specific tests.
This article was published in Behav Res Methods Instrum Comput and referenced in Endocrinology & Metabolic Syndrome

Relevant Expert PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version