alexa The mononuclear phagocyte system of the pig as a model for understanding human innate immunity and disease.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Fairbairn L, Kapetanovic R, Sester DP, Hume DA

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Abstract The biology of cells of the mononuclear phagocyte system has been studied extensively in the mouse. Studies of the pig as an experimental model have commonly been consigned to specialist animal science journals. In this review, we consider some of the many ways in which the innate immune systems of humans differ from those of mice, the ways that pigs may address the shortcomings of mice as models for the study of macrophage differentiation and activation in vitro, and the biology of sepsis and other pathologies in the living animal. With the completion of the genome sequence and the characterization of many key regulators and markers, the pig has emerged as a tractable model of human innate immunity and disease that should address the limited, predictive value of rodents in preclinical studies. This article was published in J Leukoc Biol and referenced in Journal of Cytology & Histology

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