Author(s): Nasreddine ZS, Phillips NA, Bdirian V, Charbonneau S, Whitehead V,
Abstract Share this page
Abstract OBJECTIVES: To develop a 10-minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first-line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia. DESIGN: Validation study. SETTING: A community clinic and an academic center. PARTICIPANTS: Ninety-four patients meeting MCI clinical criteria supported by psychometric measures, 93 patients with mild Alzheimer's disease (AD) (Mini-Mental State Examination (MMSE) score > or =17), and 90 healthy elderly controls (NC). MEASUREMENTS: The MoCA and MMSE were administered to all participants, and sensitivity and specificity of both measures were assessed for detection of MCI and mild AD. RESULTS: Using a cutoff score 26, the MMSE had a sensitivity of 18\% to detect MCI, whereas the MoCA detected 90\% of MCI subjects. In the mild AD group, the MMSE had a sensitivity of 78\%, whereas the MoCA detected 100\%. Specificity was excellent for both MMSE and MoCA (100\% and 87\%, respectively). CONCLUSION: MCI as an entity is evolving and somewhat controversial. The MoCA is a brief cognitive screening tool with high sensitivity and specificity for detecting MCI as currently conceptualized in patients performing in the normal range on the MMSE.
This article was published in J Am Geriatr Soc
and referenced in Journal of Gerontology & Geriatric Research