alexa The Na(V)1.7 sodium channel: from molecule to man.
Psychiatry

Psychiatry

Epilepsy Journal

Author(s): DibHajj SD, Yang Y, Black JA, Waxman SG

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Abstract The voltage-gated sodium channel Na(V)1.7 is preferentially expressed in peripheral somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion neurons. Na(V)1.7 accumulates at nerve fibre endings and amplifies small subthreshold depolarizations, poising it to act as a threshold channel that regulates excitability. Genetic and functional studies have added to the evidence that Na(V)1.7 is a major contributor to pain signalling in humans, and homology modelling based on crystal structures of ion channels suggests an atomic-level structural basis for the altered gating of mutant Na(V)1.7 that causes pain. This article was published in Nat Rev Neurosci and referenced in Epilepsy Journal

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