alexa The neutralizing antibody GNbAC1 abrogates HERV-W envelope protein-mediated oligodendroglial maturation blockade.
Neurology

Neurology

Journal of Multiple Sclerosis

Author(s): Kremer D, Frster M, Schichel T, Gttle P, Hartung HP,

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Abstract BACKGROUND: The envelope protein (ENV) of the human endogenous retrovirus type W is implicated in inflammatory reactions in multiple sclerosis (MS) but also interferes with oligodendroglial maturation. A neutralizing antibody GNbAC1 has been developed and successfully been tested in clinical trials. OBJECTIVES AND METHODS: We stimulated primary oligodendroglial cells with ENV upon preincubation with GNbAC1 and assessed for nitrosative stress and myelin expression. RESULTS: Neutralization of ENV by GNbAC1 reduces its ability to induce stress reactions resulting in a rescue of myelin expression. CONCLUSIONS: Beyond immune cell modulation, this monoclonal antibody may therefore help to overcome the oligodendroglial differentiation blockade in MS. © The Author(s), 2014. This article was published in Mult Scler and referenced in Journal of Multiple Sclerosis

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