alexa The NKG2D receptor and its ligands-recognition beyond the "missing self"?
Infectious Diseases

Infectious Diseases

Journal of Clinical Infectious Diseases & Practice

Author(s): Watzl C, Watzl C

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Abstract NKG2D is a surface receptor that activates natural killer (NK) cells and delivers a co-stimulatory signal to CD8-positive T cells. The ligands of NKG2D are induced by cellular stress and are specifically expressed by some tumor cells. This sparked the idea of an alternative regulation of NK cells by expression of "induced self" ligands on target cells which can overcome the inhibition imparted by MHC class I-specific inhibitory receptors.
This article was published in Microbes Infect and referenced in Journal of Clinical Infectious Diseases & Practice

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