alexa The order of drug administration: its effects on the interaction between cocaine and ethanol.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): PerezReyes M

Abstract Share this page

Abstract To investigate the pharmacologic effects of the interaction between cocaine and ethanol, six male, paid volunteers familiar with the use of both ethanol and cocaine were tested in a dose-response, placebo-controlled, single-blind, randomly-assigned, cross-over design. Cocaine HCl (1.25 and 1.9 mg/kg) or placebo (lidocaine and mannitol) was given by nasal insufflation (snorting). Thirty minutes after cocaine snorting, ethanol (0.85 g/kg) or placebo was administered in divided doses over a thirty minute period. Cocaine and cocaethylene plasma concentrations, blood ethanol levels, subjective ratings of drug effects, heart rate and blood pressure were measured. Statistical analysis of the effects of cocaine snorting before ethanol ingestion indicate that: 1) cocaine did not alter the blood ethanol levels or the ratings of ethanol intoxication; 2) cocaethylene was formed and appeared in plasma more slowly and in concentrations lower than those of its parent compound; 3) the appearance of cocaethylene in plasma did not alter the decline of cocaine's subjective and heart rate effects; and 4) cocaine plasma concentrations were not increased and no augmentation of the subjective and heart rate effects of cocaine occurred. This latter finding, is in sharp contrast to the significant increase in cocaine plasma concentration and augmentation of cocaine's subjective and heart rate effects produced when ethanol is ingested prior to cocaine snorting.
This article was published in Life Sci and referenced in Journal of Antivirals & Antiretrovirals

Relevant Expert PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords