Author(s): Lutter M, Sakata I, OsborneLawrence S, Rovinsky SA, Anderson JG,
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Abstract We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
This article was published in Nat Neurosci
and referenced in Journal of Molecular and Genetic Medicine