Author(s): Anzimirov VL, Romanova NV, Zhukov PV
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Abstract Orthostatic tests with printing recording of EEG, REG, RVG were used to examine the functional status of the truncal level of circulatory regulation in patients with brain confusions. Within the first 24 hours after brain injury there was a significant reduction in the pulse blood filling of cerebral vessels in the vascularization areas of carotid and vertebral arteries along with higher vascular tone; pulse blood filling of peripheral vessels in the lower extremities remained normal with a marked decrease in their vascular tone. Orthostatic tests showed the asymmetric enhancement of a dilating arterial response in the virtual absence of a constrictive response of lower extremity vessels. Following 2-3 weeks of brain injury, cerebral and peripheral hemodynamics tends to normalize: in orthostasis, the responsive dilatation of cerebral vessels diminished, inter-hemispheric asymmetry levelled; as compared to the normal values, cerebral vasodilation, however, remained enhanced with drastically suppressed peripheral vascular responsiveness. The described impaired vascular responsiveness were more evident in the presence of EEG truncal dysfunction syndromes. The findings suggest that central regulatory disorders of vascular tone play an important role in the pathogenesis of traumatic brain disease. A particular phasic periodicity of vascular responses to orthostatic exposure, which are characteristic of the acute and early rehabilitative periods of moderate brain injury.
This article was published in Zh Vopr Neirokhir Im N N Burdenko
and referenced in Journal of Nanomedicine & Nanotechnology