Author(s): Daray FM, Thommi SB, Ghaemi SN
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Abstract OBJECTIVE: Antidepressant-induced mania (AIM) has been associated with the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism in some studies but not in others. We conducted a meta-analysis of those studies and other studies of genetic predictors of AIM. METHODS: MEDLINE-based searches of genetic studies of AIM were conducted, and a meta-analysis of six studies of 5-HTTLPR was performed. Other polymorphisms were insufficiently studied to allow for meta-analysis. RESULTS: There was an association of the short (s) variant of 5-HTTLPR and AIM [risk ratio (RR) = 1.35, 95\% confidence interval (CI): 1.04-1.76, p=0.02]. There was a higher frequency of s carriers (sl and ss genotypes) in those who developed AIM [RR = 1.38, 95\% CI: 0.98-1.93), p=0.06]. CONCLUSION: The 5-HTTLPR polymorphism appears to have a moderate effect size association with AIM in patients with bipolar disorder. © 2010 John Wiley and Sons A/S.
This article was published in Bipolar Disord
and referenced in Clinical Pharmacology & Biopharmaceutics