alexa The pharmacokinetics of subcutaneous cytosine arabinoside in patients with acute myelogenous leukaemia


Chemotherapy: Open Access

Author(s): ML Slevin, Piall EM, Aherne GW, Johnston A

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1 The pharmacokinetics of subcutaneous cytosine arabinoside were compared with bolus intravenous injection and intravenous infusion in five patients with acute myelogenous leukaemia. 2 Subcutaneous cytosine arabinoside was rapidly absorbed and then declined biexponentially with initial and terminal half-lives similar to intravenous bolus injection. 3 Cytosine arabinoside levels declined rapidly after intravenous bolus and subcutaneous bolus injection, and fell below steady state infusion levels after a mean time of 40 min (intravenous bolus) and 100 min (subcutaneous injection).

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This article was published in Br J Clin Pharmacol and referenced in Chemotherapy: Open Access

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