alexa The potential of chitosan for the oral administration of peptides.
Materials Science

Materials Science

Journal of Nanomedicine & Nanotechnology

Author(s): Prego C, Torres D, Alonso MJ

Abstract Share this page

Abstract Over recent years, a major challenge in drug delivery has been the design of appropriate vehicles for the oral administration of macromolecular drugs (peptides and proteins). Indeed, despite the increasing market value of these complex molecules, their clinical use has been highly limited by their reduced oral bioavailability. Among the different delivery approaches explored so far, those based on the use of the polysaccharide chitosan have opened promising alternatives towards this ambitious goal. This is due to the interesting physicochemical and biopharmaceutical properties of this polymer. This article describes the advances that have been made in the design of chitosan-based systems specially adapted for the oral administration of peptides. These systems include solutions, microspheres, nanoparticles, nanocapsules and liposomes. More specifically, this article discusses the efficacy of the different delivery approaches for improving the absorption of peptides, and analyses the various mechanisms that have been proposed for the understanding of their efficacy. This article was published in Expert Opin Drug Deliv and referenced in Journal of Nanomedicine & Nanotechnology

Recommended Conferences

  • Nano Congress for Next Generation
    August 31-September 01, 2017 Brussels,Belgium
  • Graphene & 2D Materials
    September 14-15, 2017 Edinburgh, Scotland
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords