alexa The precision of the conjunctival provocation test.


Immunotherapy: Open Access

Author(s): Mller C, Bjrkstn B, Nilsson G, Dreborg S, Mller C, Bjrkstn B, Nilsson G, Dreborg S, Mller C, Bjrkstn B, Nilsson G, Dreborg S, Mller C, Bjrkstn B, Nilsson G, Dreborg S

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Abstract Repeated conjunctival provocation tests (CPT) were done in 20 children with rhino-conjunctivitis due to birch pollen allergy. Compared with the first open challenge, three successive blinded CPTs were reproducible within an allergen strength difference of one 10-potency in 92\% of the tests. Based on the data, a power function was constructed, making it possible to determine the number of patients needed to discriminate CPT sensitivity of a given magnitude between two populations. During the study period specific serum-IgE increased in only three of 19 patients, indicating that stimulation of IgE antibody production is not a common consequence of repeated tests. We conclude that CPT is useful in clinical research. When indicated in clinical routine, CPT is a safe and easy test with good precision.
This article was published in Allergy and referenced in Immunotherapy: Open Access

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