alexa The prevalence of hyper- and hypothyroidism in patients with ulcerative colitis.


Journal of Immunobiology

Author(s): Casella G, De Marco E, Antonelli E, Daperno M, Baldini V, , Casella G, De Marco E, Antonelli E, Daperno M, Baldini V, , Casella G, De Marco E, Antonelli E, Daperno M, Baldini V, , Casella G, De Marco E, Antonelli E, Daperno M, Baldini V,

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Abstract BACKGROUND: The association between ulcerative colitis and thyroid disorders has been previously reported. However, most reports consist of single case description, and a systematic assessment of this relationship has only sporadically been investigated. AIMS: To study a cohort of patients with ulcerative colitis to establish the prevalence of hyper- and hypothyroidism. MATERIAL AND METHODS: During a four-year period, we studied thyroid function in 162 ulcerative colitis patients (62 men, 100 women, age range 18-78 years). RESULTS: Thyroid dysfunction was present in 4 patients (2.5\%) of the overall population and was represented by both hypo- (3 patients) and hyperthyroidism (1 patient). The incidence of this kind of thyroid dysfunction was significantly (p=0.03) lower than that found in a large (more than 5000 subjects) control group. CONCLUSIONS: We conclude that the prevalence of hyper-/hypothyroidism is relatively low in patients with ulcerative colitis, at least in our country, and does not justify a systematic investigation of the thyroid function, except in selected cases, probably those with scarce or no response to standard therapeutic measures. This article was published in J Crohns Colitis and referenced in Journal of Immunobiology

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