alexa The propagation of prion-like protein inclusions in neurodegenerative diseases.


Journal of Alzheimers Disease & Parkinsonism

Author(s): Goedert M, Clavaguera F, Tolnay M

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Abstract The most common neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are characterized by the misfolding of a small number of proteins that assemble into ordered aggregates in affected brain cells. For many years, the events leading to aggregate formation were believed to be entirely cell-autonomous, with protein misfolding occurring independently in many cells. Recent research has now shown that cell non-autonomous mechanisms are also important for the pathogenesis of neurodegenerative diseases with intracellular filamentous inclusions. The intercellular transfer of inclusions made of tau, alpha-synuclein, huntingtin and superoxide dismutase 1 has been demonstrated, revealing the existence of mechanisms reminiscent of those by which prions spread through the nervous system. Copyright (c) 2010 Elsevier Ltd. All rights reserved. This article was published in Trends Neurosci and referenced in Journal of Alzheimers Disease & Parkinsonism

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