alexa The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring.
Chemistry

Chemistry

Journal of Physical Chemistry & Biophysics

Author(s): Albright RA, Ibar JL, Kim CU, Gruner SM, MoraisCabral JH

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Abstract The KtrAB ion transporter is a complex of the KtrB membrane protein and KtrA, an RCK domain. RCK domains regulate eukaryotic and prokaryotic membrane proteins involved in K(+) transport. Conflicting functional models have proposed two different oligomeric arrangements for RCK domains, tetramer versus octamer. Our results for the KtrAB RCK domain clearly show an octamer in solution and in the crystal. We determined the structure of this protein in three different octameric ring conformations that resemble the RCK-domain octamer observed in the MthK potassium channel but show striking differences in size and symmetry. We present experimental evidence for the association between one RCK octameric ring and two KtrB membrane proteins. These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK-domain octameric ring model is generally applicable to other ion-transport systems. This article was published in Cell and referenced in Journal of Physical Chemistry & Biophysics

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