alexa The relationship between neonatal developmental dysplasia of the hip and maternal hyperthyroidism.
Reproductive Medicine

Reproductive Medicine

Clinics in Mother and Child Health

Author(s): Ishikawa N

Abstract Share this page

Abstract OBJECTIVE: Development of the hip joint is complete by 11 weeks of gestation. As triiodothyronine and thyroxine are important regulators of early bone and muscle development, we hypothesized that excessive thyroid hormone in the early fetal period was a congenital risk factor of developmental dysplasia of the hip (DDH). Consequently, it was proposed that elevations of maternal thyroxine in the first trimester could alter the incidence of neonatal DDH. METHODS: The patient population comprised a retrospective cohort of all children born in Yukiguni-Yamato General Hospital from 1996 to 2003 (n = 2137). All infants were physically assessed for DDH. Pregnancies were divided into normal, Graves disease (n = 15), and severe hyperemesis gravidarum in the first trimester (n = 39, which is associated with gestational transient hyperthyroidism in up to 73\%). RESULTS: From a total 2137 pregnancies, 21 children (18 female) were diagnosed with DDH. Thirteen affected infants were from normal pregnancies (0.63\%), 3 from mothers affected with Graves disease (20\%, P < 0.0001), and 5 from mothers with hyperemesis gravidarum (12.8\%, P < 0.0001). CONCLUSIONS: Developmental dysplasia of the hip is associated with first-trimester maternal hyperthyroidism, and infants of these mothers should be closely checked for hip abnormalities. This article was published in J Pediatr Orthop and referenced in Clinics in Mother and Child Health

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]sonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords