alexa The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Fourlanos S, Varney MD, Tait BD, Morahan G, Honeyman MC, , Fourlanos S, Varney MD, Tait BD, Morahan G, Honeyman MC,

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Abstract OBJECTIVE: The rising incidence of type 1 diabetes has been attributed to environment, implying a lesser role for genetic susceptibility. However, the rise could be accounted for by either more cases with classic high-risk genes or by cases with other risk genes. Separately, for any degree of genetic susceptibility, age at presentation may decrease in a permissive environment. To examine these possibilities, human leukocyte antigen (HLA) class II DRB1 genes known to confer risk for type 1 diabetes were analyzed in relation to year of birth and age at diagnosis over the last five decades. RESEARCH DESIGN AND METHODS: Caucasoid subjects (n = 462) diagnosed with type 1 diabetes before age 18 between 1950 and 2005 were DRB1 genotyped. RESULTS: Mean +/- SD age at diagnosis, 8.5 +/- 4.5 years, did not differ across decades. Recent diagnosis was associated with a lower proportion but unchanged incidence of the highest-risk DRB1 genotype DR3,4 (2000-2005, 28\% vs. 1950-1969, 79\%; P < 0.0001) and a higher proportion of lower-risk genotypes DR4,X and DR3,X (2000-2005, 48\% vs. 1950-1969, 20\%; P = 0.0002). The frequency of the DRX,X genotype was low ( This article was published in Diabetes Care and referenced in Journal of AIDS & Clinical Research

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