alexa [The risk-benefit of high doses of botulinum toxin injections for muscle spasticity ].
Clinical Research

Clinical Research

Journal of Clinical Case Reports

Author(s): Rousseaux M, Daveluy W

Abstract Share this page

Abstract OBJECTIVE: To bring general elements of reflection on the use of the high doses of botulinum toxin in spastic children and adults. MATERIAL AND METHODS: Review of the literature on the high doses and the benefit-risk associated with botulinum toxin injections. RESULTS: The medical literature exclusively relates to the use of the high doses in children and adolescents. Comparative work with conventional doses suggests a relative interest, but with a risk of increased side effects. Several articles report on treatments with high and even very high doses in series of patient, with a documented effectiveness. But their justification remains partial and the study of the possible side effects is limited. Reflections are brought to contribute to the debate on the use of high doses, taking into account the local physiological effect of botulinum toxin, the risk of regional and general diffusion, the need for a progressive strategy, the variability of effects, the cost of the treatment and the need for obtaining an informed consent of the patient and of significant others. CONCLUSION: The use of high doses of botulinum toxin increases progressively, but must remain very careful.
This article was published in Ann Readapt Med Phys and referenced in Journal of Clinical Case Reports

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • Global Experts meeting on Oncology Case Reports
    Aug 29-31, 2017 London, UK
  • Global Experts Meeting on Case Reports
    Osaka, Japan October 09-11, 2017
  • 6th Global Experts Meeting on Medical Case Reports
    October 16-18, 2017 San Francisco, California, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version