alexa The role of AMP-activated protein kinase in mitochondrial biogenesis.


Journal of Pediatric Neurological Disorders

Author(s): Reznick RM, Shulman GI

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While it has been known for more than 75 years that physical activity is associated with increased mitochondrial content in muscle, the molecular mechanism for this adaptive process has only recently been elucidated. This brief review examines existing studies that have identified AMPK-activated protein kinase (AMPK) and several other key regulators of mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta, calcium/calmodulin-dependent protein kinase IV, and nitric oxide. In addition, the potential role of mitochondrial dysfunction in the pathogenesis of insulin resistance associated with ageing and type 2 diabetes mellitus is also discussed

This article was published in J Physiol. and referenced in Journal of Pediatric Neurological Disorders

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