Author(s): Bortner CD, Oldenburg NB, Cidlowski JA
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Abstract The formation of distinct DNA fragments of oligonucleosomal size (180-200 bp lengths) is a biochemical hallmark of apoptosis in many cells. Recent observations also suggest large DNA fragments and even single-strand cleavage events occur during cell death. These observations have raised many questions. What are the types of DNA cleavage observed during apoptosis? What are the nucleases involved? And what is the role of these nucleolytic events in apoptosis?
This article was published in Trends Cell Biol
and referenced in Pharmaceutica Analytica Acta