Author(s): Navab M, Reddy ST, Van Lenten BJ, Anantharamaiah GM, Fogelman AM
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Abstract This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport. In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.
This article was published in J Lipid Res
and referenced in Journal of Glycomics & Lipidomics