Author(s): Friedberg EC, McDaniel LD, Schultz RA
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Abstract The field of DNA damage responsiveness in general, and the consequences of endogenous and exogenous base damage in DNA, in particular, has made new and exciting contributions to our increasing understanding of the initiation and progression of neoplasia in humans. This article presents some of the highlights in this area of investigation, with a particular emphasis on DNA repair, the tolerance of DNA damage and its contribution to mutagenesis, and DNA damage checkpoint regulation.
This article was published in Curr Opin Genet Dev
and referenced in Cell & Developmental Biology