alexa The role of Granzyme B in atheromatous diseases.


Journal of Clinical & Experimental Pathology

Author(s): Chamberlain CM, Granville DJ

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Abstract The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. The current manuscript reviews our current understanding pertaining to the role of Granzyme B in cardiac allograft vasculopathy and atherosclerosis. This article was published in Can J Physiol Pharmacol and referenced in Journal of Clinical & Experimental Pathology

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