Author(s): Low PS, Waugh SM, Zinke K, Drenckhahn D
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Abstract As hemoglobin begins to denature, it forms hemichromes that cross-link the major erythrocyte membrane-spanning protein, band 3, into clusters. These clusters provide the recognition site for antibodies directed against senescent cells. These antibodies bind to the aged red cell and trigger its removal from circulation.
This article was published in Science
and referenced in Journal of Bioanalysis & Biomedicine