alexa The role of iron in doxorubicin-induced cardiomyopathy.


Biochemistry & Physiology: Open Access

Author(s): Myers C

Abstract Share this page

Abstract Doxorubicin participates in a wide range of free radical reactions. The drug can undergo one electron reduction to the corresponding semiquinone, leading the generation of superoxide and hydrogen peroxide. Additionally, the drug causes the disappearance of cardiac glutathione peroxidase, leaving the heart with no means of disposing of the hydrogen peroxide thus generated. Doxorubicin also is a powerful iron chelator and the resultant iron-drug complex is an efficient catalyst of the conversion of hydrogen peroxide to the highly reactive hydroxyl radical. Without the drug-iron complex, little or no cardiac production of hydroxyl radical occurs and heart damage does not occur.
This article was published in Semin Oncol and referenced in Biochemistry & Physiology: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  •  2nd International Conference on Biochemistry
    Sep 21-22, 2017, Macau, Hong Kong

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version