alexa The role of particle composition on the association between PM2.5 and mortality.
Genetics & Molecular Biology

Genetics & Molecular Biology

Gene Technology

Author(s): Franklin M, Koutrakis P, Schwartz P

Abstract Share this page

Abstract BACKGROUND: Although the association between exposure to particulate matter (PM) mass and mortality is well established, there remains uncertainty about which chemical components of PM are most harmful to human health. METHODS: A hierarchical approach was used to determine how the association between daily PM2.5 mass and mortality was modified by PM2.5 composition in 25 US communities. First, the association between daily PM2.5 and mortality was determined for each community and season using Poisson regression. Second, we used meta-regression to examine how the pooled association was modified by community and season-specific particle composition. RESULTS: There was a 0.74\% (95\% confidence interval = 0.41\%-1.07\%) increase in nonaccidental deaths associated with a 10 microg/m3 increase in 2-day averaged PM2.5 mass concentration. This association was smaller in the west (0.51\% [0.10\%-0.92\%]) than in the east (0.92\% [0.23\%-1.36\%]), and was highest in spring (1.88\% [0.23\%-1.36\%]). It was increased when PM2.5 mass contained a higher proportion of aluminum (interquartile range = 0.58\%), arsenic (0.55\%), sulfate (0.51\%), silicon (0.41\%), and nickel (0.37\%). The combination of aluminum, sulfate, and nickel also modified the effect. These species proportions explained residual variability between the community-specific PM2.5 mass effect estimates. CONCLUSIONS: This study shows that certain chemical species modify the association between PM2.5 and mortality and illustrates that mass alone is not a sufficient metric when evaluating health effects of PM exposure.
This article was published in Epidemiology and referenced in Gene Technology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 2nd International Conference and Expo on Generic Drug Market and Contract Manufacturing
    September 25-26, 2017 Frankfurt, Germany
  • 6th International Conference and Exhibition on Cell and Gene Therapy
    Mar 27-28, 2017 Madrid, Spain
  • 2nd World Congress on Human Genetics & Genetic Disorders
    November 02-03, 2017 Toronto, Canada

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version