alexa The role of promoter hypermethylation in fibroblast activation and fibrogenesis.


Journal of Kidney

Author(s): Zeisberg EM, Zeisberg M

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Abstract The aberrant methylation of CpG island promoters of selected genes is the prominent epigenetic mechanism by which gene transcription can be effectively silenced. Aberrant hypermethylation of a few selected genes plays an important role in facilitating fibrotic fibroblast activation and in driving fibrogenesis. Here we review mechanisms of DNA methylation and demethylation and their implications for fibroblast activation and tissue fibrosis. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. This article was published in J Pathol and referenced in Journal of Kidney

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