alexa The role of specific ions in glutamate neurotoxicity.


Journal of Addiction Research & Therapy

Author(s): Olney JW, Price MT, Samson L, Labruyere J

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Abstract When the chick embryo retina is incubated in balanced salt solution containing glutamate (Glu) in 1 mM concentration, a neurodegenerative reaction occurs within 30 min. Here we report that the neurotoxic action of Glu on retinal neurons is dependent on the presence of Na+ and Cl-, but not Ca2+, in the incubation medium. Also, we report that depolarizing concentrations of K+ can induce a severe cytotoxic reaction in chick retina which, like the depolarization-linked neurotoxicity of Glu, is a Cl- dependent phenomenon.
This article was published in Neurosci Lett and referenced in Journal of Addiction Research & Therapy

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