alexa The role of Tec family kinases in myeloid cells.
Genetics & Molecular Biology

Genetics & Molecular Biology

Gene Technology

Author(s): Schmidt U, Boucheron N, Unger B, Ellmeier W

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Abstract Members of the Tec kinase family (Bmx, Btk, Itk, Rlk and Tec) are primarily expressed in the hematopoietic system and form, after the Src kinase family, the second largest class of non-receptor protein tyrosine kinases. During lymphocyte development and activation Tec kinases have important functions in signaling pathways downstream of the antigen receptors. Tec family kinases are also expressed in cells of the myeloid lineage. However, with the exception of mast cells and platelets, their biological role in the myeloid system is only poorly understood. This review summarizes the current knowledge about the function of Tec family kinases in hematopoietic cells of the myeloid lineage. Copyright 2004 S. Karger AG, Basel This article was published in Int Arch Allergy Immunol and referenced in Gene Technology

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