alexa The Senescence Process of Internal Thoracic Artery


Journal of Molecular Histology & Medical Physiology

Author(s): Francesco Rivasi, Antonio ManLuca Roncatienti, Giuseppe Barbolini

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OBJECTIVE. The Internal Thoracic Artery (ITA) is the most widely used arterial conduit for coronary artery by-pass, because it is very rarely affected by atherosclerosis. However, the state of its wall at the time of grafting procedure could influence the long-term outcome of coronary artery by-pass. METHODS. We have investigated 20 specimens of distal human ITA, derived from 14 male patients and 6 female patients, aged between 68 and 77 years, operated for atherosclerotic coronary artery disease. The specimens, collected after surgical skeletonization during coronary artery by-pass procedures, were fixed in 10% neutral buffered formalin and then paraffin embedded. Besides to haematoxylin-eosin, histochemistry for elastic fibers (Weigert‘s staining, Van Gieson‘s staining, Verhoeff‘s staining) and immunohistochemistry for muscle cells (smooth muscle actin, caldesmon, desmin) and CD34 have been performed, applying the standard avidin-biotin complex (ABC) method. RESULTS. A degenerative pathology, most likely due to aging, characterized by the fragmentation of the internal and external elastic membranes and by the consumption of the elastic network of the tunica media has been microscopically observed in a quarter of our patients, without the achievement of classical signs of overt atherosclerosis (cholesterol deposition, lipidic infiltration, endothelial ulceration, intimal calcification), which could compromise the long-term patency of the graft. CONCLUSIONS. The degenerative change is followed by a remodelling process, based on the proliferation of unspecialized muscle like cells, able to preserve the architecture and the stability of the arterial wall and consequently its functional long-term behaviour.

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This article was published in J Interdiscipl Histopathol. and referenced in Journal of Molecular Histology & Medical Physiology

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