Author(s): Pross A, Chipman DM
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Abstract The configuration mixing (CM) model is applied to the building of a simple reaction profile for nucleophilic addition to a carbonyl group. The analysis leads us to conclude that essentially all the so-called polar reaction pathways in organic chemistry are single-electron shift processes and intimately related to the class of electron transfer (ET) reactions. The implication of this finding to a variety of organic reactions, including oxidation-reduction of the NADH/NAD+ coenzyme couple, is discussed.
This article was published in Free Radic Biol Med
and referenced in Journal of Physical Chemistry & Biophysics