alexa The single-pass perfused rabbit ear as a model for studying percutaneous absorption of clonazepam. I. General characteristics.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Proteomics & Bioinformatics

Author(s): Celesti L, Murratzu C, Valoti M, Sgaragli G, Corti P

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Abstract A single-pass perfused rabbit ear was employed as the model for studying percutaneous absorption of clonazepam in an open perfusion system. Clonazepam at 1.5\% concentration (w/w) was suspended in a gel containing 1\% (w/w) neutralized Carbopol 934 vehicled by a 50\% water solution of propylene glycol and applied to the skin, in a thermostatically controlled chamber, after 10 min pretreatment with a lauryl alcohol enhancer. At 32 degrees C, the amount of clonazepam which diffused into the effluent after a 3 h lag phase was constant for 3 h and the flux averaged 0.486 mcg/h/cm2, whereas at 25 degrees C, the flux averaged 0.424 mcg/h/cm2. The amount of drug diffusing into the effluent was a function of the contact surface area and was independent of the rate of perfusion up to values of 1 ml/min. The apparent diffusion coefficient, Ds, and the partition coefficient, KM, were 2.75/10(6)/cm/h and 5.21, respectively.
This article was published in Methods Find Exp Clin Pharmacol and referenced in Journal of Proteomics & Bioinformatics

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