alexa The SLC30 family of zinc transporters - a review of current understanding of their biological and pathophysiological roles.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Diabetes & Metabolism

Author(s): Huang L, Tepaamorndech S

Abstract Share this page

Abstract Two families of zinc (Zn(2 +)) transporters are involved in zinc homeostasis in the body, SLC30 (ZnT, zinc transporter) and SLC39 (ZIP, Zinc(Zn(2+))-Iron(Fe(2+)) Permease). The two zinc transporter family members function in opposite directions to maintain cellular zinc homeostasis. ZnT proteins contribute to the cytoplasmic zinc balance by exporting zinc out to the extracellular space or by sequestrating cytoplasmic zinc into intracellular compartments when cellular zinc levels are elevated. In contrast, ZIP proteins function to increase cytoplasmic zinc concentrations when cellular zinc is depleted. Since the cloning of the first zinc transporter (ZnT1) in 1995, there have been many advances in zinc transporter research including discovery of new members of zinc transporters, identification of gene expression patterns and regulations, recognition of protein distribution patterns in tissues and cells, and understanding of their physiological and pathological roles in humans and animal models. Ten members of the ZnT family have been identified so far. Here we give a review of these advances and discuss the pathological implications and future preventive or therapeutic applications of ZnTs. Published by Elsevier Ltd. This article was published in Mol Aspects Med and referenced in Journal of Diabetes & Metabolism

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords