alexa The stress response to trauma and surgery.
Anesthesiology

Anesthesiology

Journal of Anesthesia & Clinical Research

Author(s): Desborough JP

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The stress response is the name given to the hormonal and metabolic changes which follow injury or trauma. This is part of the systemic reaction to injury which encompasses a wide range of endocrinological, immunological and haematological effects (Table 1). The responses to surgery have been of interest to scientists for many years. In 1932, Cuthbertson described in detail the metabolic responses of four patients with lower limb injuries.10 He documented and quantified the time course of the changes. The terms ‘ebb’ and ‘flow’ were introduced to describe an initial decrease and subsequent increase in metabolic activity. The description of the ‘ebb’ phase was based partly on work in experimental animals and the estimations of increases in metabolic rate in the ‘flow’ phase were exaggerated. These descriptions have been perpetuated and are still quoted, but have been redefined29 and are perhaps not critical to an understanding of the actual changes which occur.

This article was published in Br J Anaesth. and referenced in Journal of Anesthesia & Clinical Research

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