alexa The subthalamic nucleus: a possible target for stereotaxic surgery in Parkinson's disease. Guridi J1, Luquin MR, Herrero MT, Obeso JA.
Clinical Research

Clinical Research

Journal of Clinical Research & Bioethics

Author(s): Guridi J, Luquin MR, Herrero MT, Obeso JA

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Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.

This article was published in Mov Disord and referenced in Journal of Clinical Research & Bioethics

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