alexa The synapse and cytolytic machinery of cytotoxic T cells.


Journal of Clinical & Cellular Immunology

Author(s): Jenkins MR, Griffiths GM

Abstract Share this page

Abstract Cytotoxic T lymphocytes (CTLs) rapidly kill target cells via the release of lytic granules into the immunological synapse, a process directed by the docking of the centrosome at the plasma membrane. New evidence highlights how signal strength and avidity influence the recruitment of cytolytic machinery to the synapse, and the role of each synaptic compartment. Release of cytolytic effector proteins, including perforin and FasL, is controlled at multiple levels and is also influenced by the avidity of the interaction. New imaging technologies and the use of photoactivatable peptides have allowed the dissection of signalling molecules involved in each step of the cytolytic process. This review highlights the important role of avidity in controlling how a T cell kills its target. Copyright 2010 Elsevier Ltd. All rights reserved.
This article was published in Curr Opin Immunol and referenced in Journal of Clinical & Cellular Immunology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version