alexa The TAK1-TRAF6 signalling pathway.
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Landstrm M

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Abstract Cellular responses to pathogens, growth factors, cytokines, extra- or intra-cellular stress, is a prerequisite for the cell to adapt to novel and potentially dangerous situations. If the changes in the extra- or intra-cellular milieu causes DNA-damage or revoke a signalling pathway utilized during morphogenesis, the epithelial cells might be forced to undergo programmed cell death (apoptosis) in the benefit for the whole organism or transform to a mesenchymal cell type (epithelial to mesenchymal transition; EMT), in respond to a specific stimuli. An overview is presented over the current knowledge for the key components in signal transduction in homeostasis, inflammation and cancer. A handful of transcription factors are crucial for the determination of the specific cellular responses, where the transforming growth factor-beta (TGF-beta) is an important factor as discussed in this review. 2010 Elsevier Ltd. All rights reserved. This article was published in Int J Biochem Cell Biol and referenced in Journal of Cytology & Histology

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