alexa The use of the micronucleus test on exfoliated cells to identify anti-clastogenic action in humans: a biological marker for the efficacy of chemopreventive agents.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Molecular Biomarkers & Diagnosis

Author(s): Rosin MP

Abstract Share this page

Abstract Laboratory and epidemiological studies support the hypothesis that cancer incidence in human populations can be reduced by supplementing high-risk individuals with chemopreventive agents. Many candidate agents have been identified, too many to be assayed in long-term clinical trials. As an alternate approach, intermediate markers are currently being evaluated as short-term screens for the activity of chemopreventive agents in humans. These markers quantify cellular and molecular changes of biological significance to the process of carcinogenesis. One such marker is the micronucleus test on exfoliated cells. This assay has been used to quantify chromosomal breakage occurring in the human oral cavity, esophagus, cervix, lung, nasal cavity and urinary bladder. Intervention trials on high-risk populations have shown that supplementation with chemopreventive agents can modulate this breakage. This article will review the evidence in support of the use of this assay as a biological marker for the efficacy of a chemopreventive regime. Basic problem areas in the design and conduct of this assay in humans will also be discussed, as will the future potential of the assay.
This article was published in Mutat Res and referenced in Journal of Molecular Biomarkers & Diagnosis

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 9th International Conference and Expo on Molecular & Cancer Biomarkers
    August 23-24, 2017 Birmingham, UK
  • 2nd International Conference on Medical Imaging and Diagnosis
    London, UK
  • 22nd International Conference on Cancer Drugs and Therapeutics
    Paris, France
  • International Conference on Oncology Nursing and Cancer Care
    Singapore City, Singapore
  • World Summit on Cell Signalling and Cancer Therapy
    Toronto, Canada
  • International Conference on Radiology and Imaging
    New York, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version