alexa Therapeutic applications of bone marrow-derived stem cells in ischemic stroke.


Advancements in Genetic Engineering

Author(s): Wang L, Lin Z, Shao B, Zhuge Q, Jin K

Abstract Share this page

Abstract The treatment of ischemic stroke remains a daunting task as few therapeutic strategies have proven effective. Systemic thrombolysis with intravenous tissue plasminogen activator (tPA) remains the only proven treatment to improve clinical outcome of patients with acute ischemic stroke. But because of increased risk of hemorrhage beyond 4·5 hours post-stroke, few stroke patients (1-2\%) benefit from tPA. Therefore, new therapies need to be found that protect and repair the damaged brain after stroke. The discovery of stem cells holds great promise for the cure of many diseases, including stroke. The bone marrow-derived stem cells (BMSCs) have particularly gained a great deal of attention, as BMSCs can differentiate into different lineages under specific conditions. In addition, obtaining marrow cells would be easy and using patient's own BMSCs may eliminate the risk of rejection. Therapeutic effects have been reported in animal models of stroke after transplantation of BMSCs. Initial clinical trials using BMSC transplantation have been performed in patients with ischemic stroke. Additional trials are evaluating the impact of BMSCs on safety, feasibility, and efficacy for stroke treatment. However, more information about the appropriate cell type, timing of administration, cell delivery route, and optimal dose for translational applications remains largely unexplored. This article reviews the recent progress and future perspectives in BMSC-based therapy for ischemic stroke, focusing on cell delivery route and time window of cell transplantation for treatment of ischemic stroke in animal models and clinical trials. This article was published in Neurol Res and referenced in Advancements in Genetic Engineering

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 2nd World Congress on Molecular Genetics and Gene Therapy
    July 03-05, 2017 Thailand, Bangkok
  • 3rd World Congress on Human Genetics
    August 14-15, 2017 Edinburgh, Scotland
  • International Conference on Epigenetics 2017
    November 13-15, 2017 Frankfurt, Germany
  • International Conference on Genetic Counseling and Genomic Medicine
    February 12-13, 2018 Madrid, Spain

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version