alexa Therapeutic intervention with inhibitors of co-stimulatory pathways in autoimmune disease.


Immunome Research

Author(s): Aruffo A, Hollenbaugh D

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Abstract Many humanized antibodies and fusion proteins targeting T-cell co-stimulatory molecules are now in late-stage clinical development (phase II, phase III) or have recently completed phase III clinical trials. Both Amevive, an LFA-3-Ig fusion protein targeting CD2, and Xanelim, a humanized anti-CD11a antibody, have shown efficacy in pivotal phase III trials in patients with plaque psoriasis. These new medicines are poised to enter clinical use in 2002.
This article was published in Curr Opin Immunol and referenced in Immunome Research

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