alexa Three new lignans, longipedunins A-C, from Kadsura longipedunculata and their inhibitory activity against HIV-1 protease.


Natural Products Chemistry & Research

Author(s): Sun QZ, Chen DF, Ding PL, Ma CM, Kakuda H,

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Abstract Three new lignans, longipedunins A (1), B (2) and C (3), together with three known compounds, benzoyl-binankadsurin A (4), acetyl-binankadsurin A (5) and schisanlactone A (6), were isolated from Kadsura longipedunculata. Their structures and stereochemistry were determined by spectral and single-crystal X-ray analyses. Compounds 1 and 6 showed appreciable inhibitory activity against HIV-1 protease with IC50 values of 50 and 20 microM, respectively.
This article was published in Chem Pharm Bull (Tokyo) and referenced in Natural Products Chemistry & Research

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