alexa Three possible triggers to induce thrombocytopenia in dengue virus infection.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Funahara Y, Ogawa K, Fujita N, Okuno Y

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Abstract Changes in platelet count by dengue virus-platelet interaction and the participation of anti-DV antibody to such changes were studied in vitro with the aim to investigate a mechanism of how the DV causes prominent thrombocytopenia characteristically seen in DHF. The results obtained showed that: (1) DV antigen attached to human platelets without immune-mediated reaction, (2) a decrease in platelet count was more markedly demonstrated by the binding of anti-DV antibody on the DV antigen associated with platelets than by the binding of the antigen-antibody complex on platelets, (3) a modulation of endothelial cell by the infection of DV to the cell was suggested as one of the causes of the thrombocytopenia.
This article was published in Southeast Asian J Trop Med Public Health and referenced in Journal of Bioterrorism & Biodefense

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