Author(s): Fischereder M, Jaffe JP
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Abstract An unusual case of severe thrombocytopenia following acetaminophen overdose is presented along with a retrospective review of 174 patients with hospital admissions for acute acetaminophen toxicity. Thrombocytopenia occurred in 3.4\% of these patients and strongly correlated with the degree of hepatotoxicity (as measured by peak AST values) but did not correlate with serum acetaminophen levels. The mechanism appears to be a transient direct toxic effect on platelets or megakaryocytes, and the finding of thrombocytopenia early in the course of acetaminophen overdose may identify a subset of patients at risk for significant hepatotoxicity.
This article was published in Am J Hematol
and referenced in Journal of Drug Metabolism & Toxicology