alexa Thrombocytosis
Pathology

Pathology

Journal of Clinical & Experimental Pathology

Author(s): M Vitiritti

Abstract Share this page

Thrombocytosis is defined as an increase in the number of circulating platelets than the normal value of between 150,000 and 250,000 platelets/uL. The limit beyond which the state of platelets is usually marked in platelets is defined as 400,000/uL. Trombocytosis are divided into primary or autonomous, in the course of myeloproliferative disorders (essential thrombocythemia, polycythemia vera, chronic myelogenous leukemia) and secondary or reactive. The primitive forms having a common origin as stem cells of the bone marrow, and, although each has specific characteristics, often the clinical picture overlaps, making it difficult to secure a diagnosis between these four diseases. Indeed, essentially thrombocythemia is always an increase in platelets, but this can also occur in the other three diseases, also in idiopathic thrombocythemia, sooner or later, during the course of the disease, you may have increased white blood cells and, very rarely, even red blood cells. The duration of secondary thrombocytosis is variable and tied to the possibility of removing the underlying disease. The diagnosis is based on the finding, the examination emocromocitimetrico, a higher platelet rate than 400,000 items for UL with volume, morphology and platelet function is normal, and the search for possible pathological conditions that led the platelets. Mieloroliferative diseases should be excluded from the platelets, including essential thrombocythemia, which in addition to specific hematologic abnormalities, have higher rates with strong anisomacrocitosi platelet-platelet, and more frequent bleeding or thrombotic. Several studies have shown that in most patients with polycythemia vera and in about half of those with essential thrombocythemia or idiopathic myelofibrosis, it is a single nucleotide mutation that activates JAK2. Conclusions JAK2 mutations appear to confer hypersensitivity to hematopoietic growth factors and a selective advantage for growth marrow precursors carrying the mutated gene compared with normal or wild type precursors. Recently it was discovered a point mutation dependent kinase JAK2, which involves replacing a thymine with guanine nucleotide sequence, resulting in the appearance of a valine residue instead of phenylalanine in position 617 of the amino acid sequence or JAK2617V> F. This mutation appears to be myeloid-specific and can be used for the differential diagnosis between primitive myeloproliferative disorders and secondary forms of poliglobulia or thrombocytosis.

This article was published in BMC Geriatrics and referenced in Journal of Clinical & Experimental Pathology

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords